Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase

Bioorg Med Chem Lett. 2005 Aug 1;15(15):3519-23. doi: 10.1016/j.bmcl.2005.05.096.

Abstract

A series of dianilinopyrimidineureas demonstrate potency as VEGFR2 kinase inhibitors.

MeSH terms

  • Aniline Compounds / chemistry
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology
  • HIV Protease Inhibitors / chemical synthesis
  • HIV Protease Inhibitors / pharmacology
  • Protein-Tyrosine Kinases / antagonists & inhibitors*
  • Protein-Tyrosine Kinases / metabolism
  • Pyrimidines / chemical synthesis*
  • Pyrimidines / pharmacology
  • Stereoisomerism
  • Structure-Activity Relationship
  • Urea / analogs & derivatives*
  • Urea / chemical synthesis*
  • Urea / pharmacology
  • Vascular Endothelial Growth Factor Receptor-2 / antagonists & inhibitors*
  • Vascular Endothelial Growth Factor Receptor-2 / metabolism

Substances

  • Aniline Compounds
  • Enzyme Inhibitors
  • HIV Protease Inhibitors
  • Pyrimidines
  • dianilinopyrimidineurea
  • Urea
  • Protein-Tyrosine Kinases
  • Vascular Endothelial Growth Factor Receptor-2
  • aniline